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Steps towards numerical verification of the terahertz in-line measurement of tablet mixing by means of discrete element modelling

Accepted version
Peer-reviewed

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Type

Article

Change log

Authors

Lin, H 
Pei, C 
Markl, D 
Shen, Y 
Elliott, JA 

Abstract

In recent years terahertz in-line sensing has been used to monitor the film coating thickness of individual pharmaceutical tablets during the coating process. In the previous work, the in-line measurements were verified against off-line measurements of samples from the same population. Here we report on our recent progress to further verify the validity of the terahertz in-line measurement modality using discrete element modelling for an artificial lab-scale tablet mixing process inside a tablet pan coater. By coupling discrete modelling with a ray-tracing method it is then possible to estimate the cumulative measurements taken, which in turn can guide towards the fine-tuning of the selection criteria as part of measurement analysis.

Description

Keywords

pharmaceuticals, coatings, pharmaceutical industry, ray tracing, mixing, discrete element method, numerical verification, tablet mixing, discrete element modelling, terahertz in-line sensing, film coating thickness, individual pharmaceutical tablets, measurement analysis, cumulative measurements, discrete modelling, tablet pan coater, artificial lab-scale tablet, terahertz in-line measurement modality, off-line measurements, in-line measurements, coating process

Journal Title

IET Microwaves, Antennas and Propagation

Conference Name

Journal ISSN

1751-8725
1751-8733

Volume Title

12

Publisher

Institution of Engineering and Technology (IET)
Sponsorship
Engineering and Physical Sciences Research Council (EP/L019922/1)
EPSRC Research Grants EP/L019787/1, EP/L019922/1.