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Histidine metabolism boosts cancer therapy.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Abstract

Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice.

Description

Keywords

Cancer, Medical research, Metabolism, Histidine, Humans, Methotrexate, Mutation, Neoplasms, Research

Journal Title

Nature

Conference Name

Journal ISSN

0028-0836
1476-4687

Volume Title

559

Publisher

Springer Science and Business Media LLC
Sponsorship
MRC (unknown)
Medical Research Council (MC_UU_12022/6)