Integrated plug flow synthesis and crystallisation of pyrazinamide
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Scott, C Daniel
Labes, Ricardo https://orcid.org/0000-0003-4001-0775
Depardieu, Matrin J
Battilocchio, Claudio https://orcid.org/0000-0002-4601-8527
Davidson, Matthew G
Abstract
We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.
Graphical abstract: Integrated plug flow synthesis and crystallisation of pyrazinamide
Description
Keywords
4004 Chemical Engineering, 40 Engineering
Journal Title
Reaction Chemistry & Engineering
Conference Name
Journal ISSN
2058-9883
2058-9883
2058-9883
Volume Title
3
Publisher
Royal Society of Chemistry
Publisher DOI
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/P006965/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/P006965/1)
The authors would like to acknowledge the EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies (EP/L016354/1, Davidson, Scott) for funding ... At Cambridge we acknowledge the EPSRC (EP/K009494/1 and EP/K039520/1) for support (Ley).