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Integrated plug flow synthesis and crystallisation of pyrazinamide

Published version
Peer-reviewed

Type

Article

Change log

Authors

Scott, C Daniel 
Depardieu, Matrin J 
Battilocchio, Claudio  ORCID logo  https://orcid.org/0000-0002-4601-8527
Davidson, Matthew G 

Abstract

We report the integration of flow chemistry with plug flow crystallisation. Catalytic flow hydration of pyrazinecarbonitrile to pyrazinamide was performed in a packed bed column of MnO2. The effluent of this flow reactor was directly linked to a tri-segmented tubular crystalliser (KRAIC), providing a seamless transition from flow synthesis to crystallisation, with control over solid form and particle characteristics.

Graphical abstract: Integrated plug flow synthesis and crystallisation of pyrazinamide

Description

Keywords

4004 Chemical Engineering, 40 Engineering

Journal Title

Reaction Chemistry & Engineering

Conference Name

Journal ISSN

2058-9883
2058-9883

Volume Title

3

Publisher

Royal Society of Chemistry
Sponsorship
Engineering and Physical Sciences Research Council (EP/K009494/1)
Engineering and Physical Sciences Research Council (EP/K039520/1)
Engineering and Physical Sciences Research Council (EP/P006965/1)
The authors would like to acknowledge the EPSRC Centre for Doctoral Training in Sustainable Chemical Technologies (EP/L016354/1, Davidson, Scott) for funding ... At Cambridge we acknowledge the EPSRC (EP/K009494/1 and EP/K039520/1) for support (Ley).