Through a hypertension lens, this review focuses on the serious health implications and potential counter-measures for the high volumes of uninterrupted sitting that characterises modern lifestyles. Reducing and breaking up sitting may represent a viable clinical and population health strategy to reduce blood pressure and related cardiovascular risk factors, which in contrast to moderate-vigorous physical activity, may have significant potential for widespread uptake. This review synthesises findings on the specific relationships of sedentary behaviour with BP - which primarily are from observational and acute experimental studies - including a discussion on the relevant cardiovascular mechanisms. It also considers what will need to be better understood as a basis for evidence-based recommendations on sedentary time in the context of BP control, and identify evidence gaps for future research.