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Identification of nine new susceptibility loci for endometrial cancer

Published version
Peer-reviewed

Type

Article

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Authors

Easton, DF 
Thompson, Deborah J 

Abstract

Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS) we have previously identified eight risk loci for endometrial cancer. Here, we present an expanded meta-analysis of 12,906 endometrial cancer cases and 108,979 controls (including new genotype data for 5,624 cases) and identify nine novel genome-wide significant loci, including a locus on 12q24.12 previously identified by meta-GWAS of endometrial and colorectal cancer. At five loci, expression quantitative trait locus (eQTL) analyses identify candidate causal genes and risk alleles at two of these loci that associate with decreased expression of genes which encode negative regulators of oncogenic signal transduction proteins (SH2B3 (12q24.12) and NF1 (17q11.2)). In summary, this study has doubled the number of known endometrial cancer risk loci and revealed candidate causal genes for future study.

Description

Keywords

Alleles, Biomarkers, Tumor, Chromatin, Endometrial Neoplasms, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Polymorphism, Single Nucleotide, Quantitative Trait Loci, Risk Factors, Signal Transduction

Journal Title

Nature Communications

Conference Name

Journal ISSN

2041-1723
2041-1723

Volume Title

9

Publisher

Springer Nature
Sponsorship
Cancer Research UK (16565)
Medical Research Council (MC_UU_12015/2)
National Cancer Institute (U19CA148537)
National Cancer Institute (R01CA128978)
National Cancer Institute (U19CA148065)
European Commission (223175)
National Health and Medical Research Council (1109286)
Cancer Research UK (A10710)
Cancer Research UK (A12014)
Cancer Research UK (A10118)
National Health and Medical Research Council (1109286)
National Health and Medical Research Council (1031333)
Cancer Research UK (A16563)