Ten things you should know about transposable elements.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Bourque, Guillaume https://orcid.org/0000-0002-3933-9656
Burns, Kathleen H
Gehring, Mary
Gorbunova, Vera
Seluanov, Andrei
Abstract
Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.
Description
Keywords
Animals, DNA Transposable Elements, Gene Rearrangement, Humans, Mutation, Polymorphism, Genetic
Journal Title
Genome Biol
Conference Name
Journal ISSN
1474-7596
1474-760X
1474-760X
Volume Title
19
Publisher
Springer Science and Business Media LLC
Publisher DOI
Sponsorship
Wellcome Trust (206688/Z/17/Z)