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Ten things you should know about transposable elements.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Burns, Kathleen H 
Gehring, Mary 
Gorbunova, Vera 
Seluanov, Andrei 

Abstract

Transposable elements (TEs) are major components of eukaryotic genomes. However, the extent of their impact on genome evolution, function, and disease remain a matter of intense interrogation. The rise of genomics and large-scale functional assays has shed new light on the multi-faceted activities of TEs and implies that they should no longer be marginalized. Here, we introduce the fundamental properties of TEs and their complex interactions with their cellular environment, which are crucial to understanding their impact and manifold consequences for organismal biology. While we draw examples primarily from mammalian systems, the core concepts outlined here are relevant to a broad range of organisms.

Description

Keywords

Animals, DNA Transposable Elements, Gene Rearrangement, Humans, Mutation, Polymorphism, Genetic

Journal Title

Genome Biol

Conference Name

Journal ISSN

1474-7596
1474-760X

Volume Title

19

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (206688/Z/17/Z)