INTRODUCTION: The study presented one of the first examinations of the associations among personality, alcohol-related protective behavioural strategies (PBS), alcohol consumption, sexual intercourse and sex-related alcohol negative consequences in Irish, female college students (n = 522). METHODS: A cross-sectional observational design was employed and participants completed the study online. Participants completed measures of personality, alcohol-related PBS, alcohol consumption and sexual intercourse. Hierarchical multiple regression was utilised to access the associations between such measures. RESULTS: From the analyses, it was found that age, frequency of sexual intercourse, frequency of alcohol consumption, level of alcohol consumption and openness were all significantly related to the use of alcohol-related protective behavioural strategies, and in turn, sex-related negative consequences. However, inconsistent findings with other personality dimensions to those of previous research were noted. CONCLUSIONS: The findings of this study posited that the use of PBS has a key role to play in the levels of sexual intercourse and alcohol consumption, age and openness, and the associated negative sexual consequences in Irish, female college students.