Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.
Description
Keywords
Journal Title
Conference Name
Journal ISSN
1546-1718
Volume Title
Publisher
Publisher DOI
Sponsorship
MRC (MC_PC_13048)
MRC (MC_PC_13046)
Department of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
Medical Research Council (MR/S003746/1)