Grking the Smoothened signal.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Sharpe, Hayley J
de Sauvage, Frederic J
Abstract
The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal transducer Smoothened. Two reports by Liet aland Pusapatiet alin this issue ofScience Signalingprovide new insights into the role of GRK2 in HH signaling.
Description
Keywords
Cell Movement, Hedgehog Proteins, Signal Transduction, Smoothened Receptor, Ubiquitin-Protein Ligases
Journal Title
Science signaling
Conference Name
Journal ISSN
1937-9145
1937-9145
1937-9145
Volume Title
11
Publisher
American Association for the Advancement of Science
Publisher DOI
Sponsorship
Wellcome Trust (109407/Z/15/Z)