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Grking the Smoothened signal.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Sharpe, Hayley J 
de Sauvage, Frederic J 

Abstract

The kinase GRK2 has been linked to the clinically important Hedgehog (HH) signaling pathway, where it is paradoxically required for signal transduction yet also promotes internalization and degradation of the critical HH signal transducer Smoothened. Two reports by Liet aland Pusapatiet alin this issue ofScience Signalingprovide new insights into the role of GRK2 in HH signaling.

Description

Keywords

Cell Movement, Hedgehog Proteins, Signal Transduction, Smoothened Receptor, Ubiquitin-Protein Ligases

Journal Title

Science signaling

Conference Name

Journal ISSN

1937-9145
1937-9145

Volume Title

11

Publisher

American Association for the Advancement of Science
Sponsorship
Wellcome Trust (109407/Z/15/Z)