Oligodendrocyte progenitor cells become regionally diverse and heterogeneous with age
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Peer-reviewed
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Oligodendrocyte progenitor cells (OPCs), which differentiate into myelinating oligodendrocytes during central nervous system (CNS) development, are the main proliferative cells in the adult brain. OPCs are conventionally considered a homogeneous population, particularly with respect to their electrophysiological properties, but this has been debated. We show, by using single-cell electrophysiological recordings, that OPCs start out as a homogeneous population, but become functionally heterogeneous, varying both within and between brain regions and with age. These electrophysiological changes in OPCs correlate with the differentiation potential of OPCs; thus, they may underlie the differentiational differences in OPCs between regions and likewise differentiation failure with age.
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1097-4199
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Lister Institute of Preventive Medicine (unknown)
Paul G Allen Family Foundation (12076)
European Research Council (771411)
Wellcome Trust (102160/B/13/Z)
Medical Research Council (MC_PC_12009)
Medical Research Council (MC_PC_15042)
Multiple Sclerosis Society (50)
Medical Research Council (G0701476)