Data on hyper-activation of GPVI signalling in obese patients: Towards the identification of novel antiplatelet targets in obesity.
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Barrachina, María N
Izquierdo, Irene
Hermida-Nogueira, Lidia
Sueiro, Aurelio M
Guitián, Esteban
Abstract
This data article is associated with the manuscript "GPVI surface expression and signalling pathway activation are increased in platelets from obese patients: elucidating potential anti-atherothrombotic targets in obesity" [1]. The study refers to a combination of different approaches in order to identify platelet-derived biomarkers in obesity. A total of 34 obese patients and their lean-matched controls were included in the study. We carried out a proteomic and functional (aggregation assays) analysis to find alterations in platelet-derived signalling pathways. After that, biochemical and mechanistic (flow cytometry assays) approaches were done in order to confirm a hyperactivation of the GPVI-related signalling pathway.
Description
Keywords
3101 Biochemistry and Cell Biology, 32 Biomedical and Clinical Sciences, 31 Biological Sciences, Obesity, Nutrition, Clinical Research, Hematology, 2.1 Biological and endogenous factors, 2 Aetiology, Cardiovascular, Stroke, Cancer
Journal Title
Data Brief
Conference Name
Journal ISSN
2352-3409
2352-3409
2352-3409
Volume Title
23
Publisher
Elsevier BV
Publisher DOI
Sponsorship
British Heart Foundation (PG/18/36/33811)
British Heart Foundation (RG/15/4/31268)
British Heart Foundation (RG/15/4/31268)
Spanish Ministry of Economy and Competitiveness (MINECO) [grant No. SAF2016-79662-R]
European Regional Development Fund (ERDF).
Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia (Centro Singular de investigación de Galicia accreditation 2016-2019, ED431G/05)
European Regional Development Fund (ERDF)
British Heart Foundation, grants SP/13/7/30575, PG/18/36/338, and RG/15/4/31268.