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Using prognosis to guide early detection and treatment selection in non-metastatic prostate cancer.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Gnanapragasam, Vincent J  ORCID logo  https://orcid.org/0000-0003-4722-4207
Barrett, Tristan 
Massie, Charlie 
Pacey, Simon 
Warren, Anne 

Abstract

Over recent years there has been an increasing awareness that our ideas on the lethality of primary non‐metastatic prostate cancer may need to change. This concept has emerged from a number of different sources including randomised controlled trials, reports from mature active surveillance programmes, and prognostic modelling work in large populations 1, 2. The evidence suggests that for many men without metastatic disease (85% of all presentations from the recent UK National Prostate Cancer Audit) tumours will evolve slowly and will not translate into cancer‐related mortality, at least, not within the first 10–15 years of its natural history.

Description

Keywords

Decision Support Techniques, Disease Progression, Early Detection of Cancer, Humans, Lymphatic Metastasis, Male, Patient Selection, Prognosis, Prostatic Neoplasms, Unnecessary Procedures

Journal Title

BJU Int

Conference Name

Journal ISSN

1464-4096
1464-410X

Volume Title

123

Publisher

Wiley
Sponsorship
Cancer Research UK (26718)