RNA modifications regulating cell fate in cancer.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
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Authors
Delaunay, Sylvain
Frye, Michaela https://orcid.org/0000-0002-5636-6840
Abstract
The deposition of chemical modifications into RNA is a crucial regulator of temporal and spatial gene expression programs during development. Accordingly, altered RNA modification patterns are widely linked to developmental diseases. Recently, the dysregulation of RNA modification pathways also emerged as a contributor to cancer. By modulating cell survival, differentiation, migration and drug resistance, RNA modifications add another regulatory layer of complexity to most aspects of tumourigenesis.
Description
Keywords
Cell Differentiation, Cell Lineage, Cell Movement, Cell Proliferation, Cell Survival, Gene Expression Regulation, Neoplastic, Humans, Neoplasms, RNA, RNA Processing, Post-Transcriptional
Journal Title
Nat Cell Biol
Conference Name
Journal ISSN
1465-7392
1476-4679
1476-4679
Volume Title
21
Publisher
Springer Science and Business Media LLC
Publisher DOI
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All rights reserved
Sponsorship
Cancer Research Uk (None)
European Research Council (310360)
Medical Research Council (MR/M01939X/1)
European Research Council (310360)
Medical Research Council (MR/M01939X/1)
M.F. is supported by a Cancer Research UK Senior Fellowship (C10701/A15181), the European Research Council (ERC; 310360), and the Medical Research Council UK (MR/M01939X/1). S.D. is funded by an EMBO Long-Term Fellowship. Part of this work was carried out in the framework of the European COST action EPITRAN 16120