Detection, Structure and Function of Modified DNA Bases.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Hofer, Alexandre https://orcid.org/0000-0001-6396-3689
Liu, Zheng J
Balasubramanian, Shankar https://orcid.org/0000-0002-0281-5815
Abstract
While some DNA base modifications such as 5-methylcytosine have been known and studied for decades, recent discoveries of a number of other modified bases have stimulated research to understand their origin and function. Chemistry-based methods for their detection and analysis have proven to be important for advancing the field. Here, we feature a selection of methods that have helped advance the field, along with some key advances in the understanding of how the chemistry of modified bases affects biological functions. We also discuss fundamental questions in the field that remain unanswered.
Description
Keywords
Base Pairing, Chromatography, Liquid, DNA, Methylation, Molecular Structure, Tandem Mass Spectrometry
Journal Title
J Am Chem Soc
Conference Name
Journal ISSN
0002-7863
1520-5126
1520-5126
Volume Title
141
Publisher
American Chemical Society (ACS)
Publisher DOI
Rights
All rights reserved
Sponsorship
Wellcome Trust (209441/Z/17/Z)
European Commission Horizon 2020 (H2020) Marie Sklodowska-Curie actions (789407)
European Commission Horizon 2020 (H2020) Marie Sklodowska-Curie actions (789407)
Swiss National Science Foundation
EU H2020 Framework Programme