Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future.
Accepted version
Peer-reviewed
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Abstract
Spike-timing-dependent synaptic plasticity (STDP) is a leading cellular model for behavioral learning and memory with rich computational properties. However, the relationship between the millisecond-precision spike timing required for STDP and the much slower timescales of behavioral learning is not well understood. Neuromodulation offers an attractive mechanism to connect these different timescales, and there is now strong experimental evidence that STDP is under neuromodulatory control by acetylcholine, monoamines, and other signaling molecules. Here, we review neuromodulation of STDP, the underlying mechanisms, functional implications, and possible involvement in brain disorders.
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Keywords
STDP, attention, disease, long-term depression, long-term potentiation, memory, neurodevelopment, neuromodulation, reinforcement learning, sleep, spike-timing-dependent plasticity, synaptic plasticity, Action Potentials, Animals, Astrocytes, Behavior, Brain Diseases, Brain Mapping, Humans, Learning, Memory Consolidation, Models, Neurological, Molecular Targeted Therapy, Neurodegenerative Diseases, Neurodevelopmental Disorders, Neuronal Plasticity, Neurons, Neurotransmitter Agents, Obsessive-Compulsive Disorder, Presynaptic Terminals, Receptors, Neurotransmitter, Reinforcement, Psychology, Signal Transduction, Species Specificity, Stroke, Substance-Related Disorders, Time Factors
Journal Title
Neuron
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Journal ISSN
0896-6273
1097-4199
1097-4199
Volume Title
103
Publisher
Elsevier BV
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Sponsorship
Biotechnology and Biological Sciences Research Council (BB/N019008/1)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (700999)
Biotechnology and Biological Sciences Research Council (BB/P019560/1)
Biotechnology and Biological Sciences Research Council (BB/N00096X/1)
Biotechnology and Biological Sciences Research Council (BB/H002383/2)
European Commission Horizon 2020 (H2020) Marie Sk?odowska-Curie actions (700999)
Biotechnology and Biological Sciences Research Council (BB/P019560/1)
Biotechnology and Biological Sciences Research Council (BB/N00096X/1)
Biotechnology and Biological Sciences Research Council (BB/H002383/2)
BBSRC