The Aire family expands.
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Peer-reviewed
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Abstract
T cell tolerance depends upon Aire-expressing cells to purge the T cell repertoire of autoreactive clones. Once thought to be the exclusive domain of thymic epithelial cells, a new study by Yamano et al. (https://doi.org/10.1084/jem.20181430) in this issue of JEM identifies ILC3-like cells in the lymph nodes with similar properties.
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Keywords
Epithelial Cells, Immune Tolerance, Lymph Nodes, T-Lymphocytes
Journal Title
J Exp Med
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Journal ISSN
0022-1007
1540-9538
1540-9538
Volume Title
216
Publisher
Rockefeller University Press
