Energy coupling in ABC exporters.
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Peer-reviewed
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Abstract
Multidrug transporters are important and interesting molecular machines that extrude a wide variety of cytotoxic drugs from target cells. This review summarizes novel insights in the energetics and mechanisms of bacterial ATP-binding cassette multidrug transporters as well as recent advances connecting multidrug transport to ion and lipid translocation processes in other membrane proteins.
Description
Keywords
ABC transporter, Bioenergetics, Multidrug transport, Transport mechanisms, ATP-Binding Cassette Transporters, Adenosine Triphosphate, Anti-Bacterial Agents, Bacteria, Biological Transport, Drug Resistance, Multiple, Bacterial, Energy Metabolism, Protein Conformation
Journal Title
Research in Microbiology
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Journal ISSN
0923-2508
1769-7123
1769-7123
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Publisher
Elsevier
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Sponsorship
Biotechnology and Biological Sciences Research Council (BB/I002383/1)
Human Frontier Science Program (HFSP) (RPG0034/2013)
Biotechnology and Biological Sciences Research Council (BB/R00224X/1)
MRC (MC_PC_14116 v2)
Biotechnology and Biological Sciences Research Council (2114197)
Biotechnology and Biological Sciences Research Council (BB/K017713/1)
Human Frontier Science Program (HFSP) (RPG0034/2013)
Biotechnology and Biological Sciences Research Council (BB/R00224X/1)
MRC (MC_PC_14116 v2)
Biotechnology and Biological Sciences Research Council (2114197)
Biotechnology and Biological Sciences Research Council (BB/K017713/1)