Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Castro-Bravo, Nuria
Margolles, Abelardo
Wells, Jerry M
Ruas-Madiedo, Patricia
Abstract
The toll-like receptors involved in recognition of the exopolysaccharide produced by two isogenic, ropy and non-ropy, Bifidobacterium animalis subsp. lactis strains were investigated. Both strains interact with human embryonic kidney (HEK)-293 cells via TLR2, whereas purified EPSs specifically stimulate TLR4 regardless their molar mass.
Description
Keywords
Bifidobacterium animalis, Cell Line, Epithelial Cells, Humans, Polysaccharides, Bacterial, Protein Binding, Toll-Like Receptor 4
Journal Title
Anaerobe
Conference Name
Journal ISSN
1075-9964
1095-8274
1095-8274
Volume Title
56
Publisher
Elsevier
Publisher DOI
Sponsorship
The MicroHealth group acknowledge the project AGL2015-64901-R (including FEDER European Union funds) from the Ministry of Economy, Industry and Competiveness (MINECO). N. Castro-Bravo thanks her FPI fellowship to the MINECO (BES2013-063984).