Neural stem cell dynamics: the development of brain tumours.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Hakes, Anna E
Brand, Andrea H
Abstract
Determining the premalignant lesions that develop into malignant tumours remains a daunting task. Brain tumours are frequently characterised by a block in differentiation, implying that normal developmental pathways become hijacked during tumourigenesis. However, the heterogeneity of stem cells and their progenitors in the brain suggests there are many potential routes to tumour initiation. Studies in Drosophila melanogaster have enhanced our understanding of the tumourigenic potential of distinct cell types in the brain. Here we review recent studies that have improved our knowledge of neural stem cell behaviour during development and in brain tumour models.
Description
Keywords
Animals, Brain Neoplasms, Cell Lineage, Drosophila melanogaster, Humans, Models, Biological, Neural Stem Cells, Time Factors
Journal Title
Current Opinion in Cell Biology
Conference Name
Journal ISSN
0955-0674
1879-0410
1879-0410
Volume Title
60
Publisher
Elsevier
Publisher DOI
Rights
All rights reserved
Sponsorship
Wellcome Trust (103792/Z/14/Z)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (102454/Z/13/Z)
Cancer Research Uk (None)
Royal Society (RP150061)
Wellcome Trust (092096/Z/10/Z)
Wellcome Trust (102454/Z/13/Z)
Cancer Research Uk (None)
Royal Society (RP150061)
This work was funded by: Wellcome Trust Senior Investigator Award (103792 to A.H.B.), The Royal Society Darwin Trust Research Professorship (to A.H.B.) and Wellcome Trust PhD Studentship (102454 to A.E.H.). A.H.B acknowledges core funding to The Gurdon Institute from the Wellcome Trust (092096) and CRUK (C6946/A14492).