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Targeting senescent cells in translational medicine.

Published version
Peer-reviewed

Type

Article

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Authors

Paez-Ribes, Marta 
González-Gualda, Estela 
Doherty, Gary J 
Muñoz-Espín, Daniel  ORCID logo  https://orcid.org/0000-0002-0550-9514

Abstract

Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a hallmark of ageing. Senescent cells accumulate in multiple organs during ageing, contribute to tissue dysfunction and give rise to pathological manifestations. Senescence is therefore a defining feature of a variety of human age-related disorders, including cancer, and targeted elimination of these cells has recently emerged as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration. In addition, in vivo identification of senescent cells has significant potential for early diagnosis of multiple pathologies. Here, we review existing senolytics, small molecules and drug delivery tools used in preclinical therapeutic strategies involving cellular senescence, as well as probes to trace senescent cells. We also review the clinical research landscape in senescence and discuss how identifying and targeting cellular senescence might positively affect pathological and ageing processes.

Description

Funder: La Caixa" Foundation

Keywords

Cellular senescence, SASP, Age-related Disorders, Senolytic Drugs, Senoprobes

Journal Title

Conference Name

Journal ISSN

1757-4676

Volume Title

Publisher

Sponsorship
Cancer Research UK (C62187/A26989)
Royal Society (RG160806)
University of Cambridge (C9685/125117)
UK Research and Innovation|Medical Research Council (MRC) (MR/R000530/1)