Dopaminergic modulation of reinforcement learning in stimulant drug addiction
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Peer-reviewed
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Abstract
Background: Chronic stimulant use has been associated with disruptions in fronto-striatal systems implicated in as- sociative learning [1]. Experimental studies have also shown that individuals with stimulant drug addiction experience difficulties in selecting the appropriate action following feedback [2]. However, the precise impairments in feedback learning in stimulant-addicted individuals are still unclear. A possible explanation might lie in an abnormal prediction error mechanism, as stimulant drugs directly target striatal dopaminergic neurons [3].
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Keywords
5202 Biological Psychology, 32 Biomedical and Clinical Sciences, 3209 Neurosciences, 52 Psychology
Journal Title
EUROPEAN NEUROPSYCHOPHARMACOLOGY
Conference Name
32nd ECNP Congress
Journal ISSN
0924-977X
1873-7862
1873-7862
Volume Title
29
Publisher
Elsevier BV
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All rights reserved
Sponsorship
Medical Research Council (MC_PC_17213)
Wellcome Trust; support from NIHR Cambridge BRC