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RORĪ³t+ Treg to Th17 ratios correlate with susceptibility to Giardia infection.

Published version
Peer-reviewed

Type

Article

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Authors

CortĆ©s, Alba 
Klotz, Christian 
KĆ¼hl, Anja A 
Heimesaat, Markus M 

Abstract

Infections with Giardia are among the most common causes of food and water-borne diarrheal disease worldwide. Here, we investigated Th17, Treg and IgA responses, and alterations in gut microbiota in two mouse lines with varying susceptibility to Giardia muris infection. Infected BALB/c mice shed significantly more cysts compared with C57BL/6 mice. Impaired control of infection in BALB/c mice was associated with lower Th17 activity and lower IgA levels compared with C57BL/6 mice. The limited metabolic activity, proliferation and cytokine production of Th17 cells in BALB/c mice was associated with higher proportions of intestinal Foxp3+RORĪ³t+ regulatory T cells and BALB/c mice developed increased RORĪ³t+ Treg:Th17 ratios in response to G. muris infection. Furthermore, G. muris colonization led to a significantly reduced evenness in the gut microbial communities of BALB/c mice. Our data indicate that differential susceptibility to Giardia infections may be related to RORĪ³t+ Treg controlling Th17 activity and that changes in the microbiota composition upon Giardia infection partially depend on the host background.

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Journal Title

Scientific reports, volume 9, issue 1

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Journal ISSN

2045-2322

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Sponsorship
Deutsche Forschungsgemeinschaft (German Research Foundation) (GRK2046)
Bundesministerium fĆ¼r Bildung und Forschung (Federal Ministry of Education and Research) (IP7/01KI1725D)