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Targeting senescent cells in translational medicine.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Paez-Ribes, Marta 
González-Gualda, Estela 
Doherty, Gary J 
Muñoz-Espín, Daniel  ORCID logo  https://orcid.org/0000-0002-0550-9514

Abstract

Organismal ageing is a complex process driving progressive impairment of functionality and regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest occurring in response to damage and stress and is considered a hallmark of ageing. Senescent cells accumulate in multiple organs during ageing, contribute to tissue dysfunction and give rise to pathological manifestations. Senescence is therefore a defining feature of a variety of human age-related disorders, including cancer, and targeted elimination of these cells has recently emerged as a promising therapeutic approach to ameliorate tissue damage and promote repair and regeneration. In addition, in vivo identification of senescent cells has significant potential for early diagnosis of multiple pathologies. Here, we review existing senolytics, small molecules and drug delivery tools used in preclinical therapeutic strategies involving cellular senescence, as well as probes to trace senescent cells. We also review the clinical research landscape in senescence and discuss how identifying and targeting cellular senescence might positively affect pathological and ageing processes.

Description

Keywords

SASP, age-related disorders, cellular senescence, senolytic drugs, senoprobes, Aging, Animals, Cellular Senescence, Humans, Translational Research, Biomedical

Journal Title

EMBO Mol Med

Conference Name

Journal ISSN

1757-4676
1757-4684

Volume Title

11

Publisher

Springer Science and Business Media LLC
Sponsorship
Medical Research Council (MR/R000530/1)
Royal Society (160806)
Cancer Research UK (A26989)