Research data supporting 'Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity'
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Dataset
Change log
Authors
Zacharopoulou, Maria
Moons, Rani
Fusco, Giuliana
Seetaloo, Neeleema
Description
Raw data files supporting the manuscript 'Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity'. Including raw HDX-MS data for up to 6 replicates for two labelling conditions (with and without Ca2+) and MS/MS mapping files. Raw nano-ESI-EM and nano-ESI-IM-MS data of three replicates with and without Ca2+. Raw NMR data files for three aSyn varients with and without Ca2+. Raw ThT-based aggregation kinetic data. Additional AFM files. Primer sequences.
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Software / Usage instructions
HDX-MS data - Excel
ESI-MS and ESI-IM-MS data - Excel
NMR data - Sparky 3.1
ThT data - Excel
Keywords
synuclein, amyloid, monomer, long-range interactions
