Do mutations turn p53 into an oncogene?
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Pitolli, Consuelo
Wang, Ying
Mancini, Mara
Shi, Yufang
Amelio, Ivano https://orcid.org/0000-0002-9126-5391
Abstract
The key role of p53 as a tumor suppressor became clear when it was realized that this gene is mutated in 50% of human sporadic cancers and germline mutations expose to cancer along lifespan. Mutations in this gene not only abolish the tumor suppressive functions of p53 but also equip the protein with new pro-oncogenic functions. Here, we review the mechanisms by which these new functions gained by p53 mutants promote tumorigenesis.
Description
Keywords
TP53, gain of function, mutant TP53, oncogenic, Animals, Drug Resistance, Neoplasm, Humans, Mutation, Neoplasms, Oncogenes, Tumor Hypoxia, Tumor Suppressor Protein p53
Journal Title
International Journal of Molecular Sciences
Conference Name
Journal ISSN
1422-0067
1422-0067
1422-0067
Volume Title
20
Publisher
MDPI AG