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A compact synthetic aperture digital holographic microscope with mechanical movement-free beam scanning and optimized active aberration compensation for isotropic resolution enhancement

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Deng, Yuanbo 
Huang, Chung-Hsuan 
Vinoth, B 
Lai, Xin-Ji 

Abstract

This study proposes and demonstrates a compact synthetic aperture digital holographic microscope (SA-DHM) with mechanical movement-free beam scanning and optimized active aberration compensation. The SA-DHM system is equipped with a phase-only liquid crystal on silicon (LCoS) device as an active optical element to achieve a compact mechanical movement-free beam steering architecture with aberration correction. A rigorous optimization is conducted to modulate the LCoS device using the designed computer-generated holograms (CGH) to generate a high-quality point spread functions (PSF) for a wide range of scanning angles. An accurate aberration correction is studied with and without oil immersed conditions on microscope objective lens. The performance of the proposed method is analyzed with Siemens star target and the results show its potential capability to achieve isotropic resolution enhancement.

Description

Keywords

40 Engineering, 4009 Electronics, Sensors and Digital Hardware, Bioengineering

Journal Title

Optics and Lasers in Engineering

Conference Name

Journal ISSN

0143-8166
1873-0302

Volume Title

134

Publisher

Elsevier BV
Sponsorship
Engineering and Physical Sciences Research Council (EP/L015455/1)
Royal Society (IE151020)