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Compulsivity is linked to reduced adolescent development of goal-directed control and frontostriatal functional connectivity.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Vaghi, Matilde M 
Moutoussis, Michael  ORCID logo  https://orcid.org/0000-0002-4751-0425
Váša, František 

Abstract

A characteristic of adaptive behavior is its goal-directed nature. An ability to act in a goal-directed manner is progressively refined during development, but this refinement can be impacted by the emergence of psychiatric disorders. Disorders of compulsivity have been framed computationally as a deficit in model-based control, and have been linked also to abnormal frontostriatal connectivity. However, the developmental trajectory of model-based control, including an interplay between its maturation and an emergence of compulsivity, has not been characterized. Availing of a large sample of healthy adolescents (n = 569) aged 14 to 24 y, we show behaviorally that over the course of adolescence there is a within-person increase in model-based control, and this is more pronounced in younger participants. Using a bivariate latent change score model, we provide evidence that the presence of higher compulsivity traits is associated with an atypical profile of this developmental maturation in model-based control. Resting-state fMRI data from a subset of the behaviorally assessed subjects (n = 230) revealed that compulsivity is associated with a less pronounced change of within-subject developmental remodeling of functional connectivity, specifically between the striatum and a frontoparietal network. Thus, in an otherwise clinically healthy population sample, in early development, individual differences in compulsivity are linked to the developmental trajectory of model-based control and a remodeling of frontostriatal connectivity.

Description

Keywords

adolescence, compulsivity, development, frontostriatal connectivity, model-based control, Adolescent, Adolescent Development, Adult, Compulsive Behavior, Corpus Striatum, Female, Goals, Humans, Magnetic Resonance Imaging, Male, Young Adult

Journal Title

Proc Natl Acad Sci U S A

Conference Name

Journal ISSN

0027-8424
1091-6490

Volume Title

117

Publisher

Proceedings of the National Academy of Sciences

Rights

All rights reserved
Sponsorship
Cambridge University Hospitals NHS Foundation Trust (CUH) (146281)
Department of Health (via National Institute for Health Research (NIHR)) (156239)
MQ: Transforming Mental Health (MQ17-24 Vertes)
MRC (unknown)
Wellcome Trust (095844/Z/11/Z)
Guarantors of Brain (unknown)
Medical Research Council (MC_G0802534)
Medical Research Council (MC_UP_1401/1)
Medical Research Council (MC_UU_00005/9)
Wellcome Trust (107392/Z/15/Z)
Wellcome Trust National Institute of Health Research