Research question How are IVF clinic websites advertising three common IVF add-ons: assisted hatching, time-lapse embryo imaging and preimplantation genetic testing for aneuploidy (PGT-A)?

Design The HFEA “Choose a fertility clinic” website was used to identify IVF clinics and their websites. Assisted hatching, time-lapse embryo imaging and PGT-A were examined to determine which websites advertised them, what price they charged and what claims they made in relation to the add-ons.

Results We identified 87 eligible clinics, with 72 unique websites. 37 (43%) clinics were part of one of 9 groups of IVF clinics, of size ranging from 2 to 8 clinics. Time-lapse was the most frequently advertised of the three add-ons (67% of clinics), followed by PGT-A (47%) and then assisted hatching (28%). Very few websites stated that the effectiveness of the add-on was in doubt or unclear (respectively, 1, 4, and 2 websites for assisted hatching, time-lapse, and PGT-A), and none raised the possibility that an add-on might have negative effects. Claims of efficacy were often based on upstream outcomes (e.g. implantation, pregnancy). Some claims that PGT-A and time-lapse improved live birth rates were found. There was substantial variation in pricing.

Conclusions IVF clinic websites provide valuable information for patients seeking fertility treatment so it is key that this information is accurate and complete. There is a need for transparent information on interventions to be made available by IVF clinics, including any uncertainties and risks, to support well-informed treatment decisions. The selected add-ons are widely advertised, and there is wide variation in pricing.

key messages 67% of clinics advertised time lapse47% PGT-A28% assisted hatching. There is substantial variation in pricing for the add-ons. Few stated that evidence of effectiveness was in doubtand none stated that add-ons might reduce the chance of success