Italian politics has always been characterised by deep regional divides. While the north and centre are well integrated into the European economy, southern regions struggle to keep up their productivity and employment levels. Although this divide has a long history, the Covid-19 crisis is set to worsen the inequality separating the two parts of the country. In this article, I first discuss how the coronavirus pandemic immediately assumed a regional dimension, which was reflected not only in the geography of the contagion, but also in how the central state struggled to manage the contrasting demands coming from northern and southern regions. Second, I argue that, although the north has been the epicentre of the health crisis, it is the south that is set to pay the highest economic and social price for the lockdown measures. I conclude suggesting that, while the Covid crisis has confirmed the salience of regional divides for Italian politics, it might also strengthen autonomist forces.