Sequential dual site-selective protein labelling enabled by lysine modification.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Abstract
Methods that allow for chemical site-selective dual protein modification are scarce. Here, we provide proof-of-concept for the orthogonality and compatibility of a method for regioselective lysine modification with strategies for protein modification at cysteine and genetically encoded ketone-tagged amino acids. This sequential, orthogonal approach was applied to albumin and a therapeutic antibody to create functional dual site-selectively labelled proteins.
Description
Keywords
Albumin, Antibodies, Bioorthogonal labelling, Lysine modification, Protein modification, Albumins, Antibodies, Lysine, Molecular Structure, Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
Journal Title
Bioorg Med Chem
Conference Name
Journal ISSN
0968-0896
1464-3391
1464-3391
Volume Title
28
Publisher
Elsevier BV
Publisher DOI
Sponsorship
Royal Society (URF\R\180019)