Disentangling PTEN-cooperating tumor suppressor gene networks in cancer.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
de la Rosa, Jorge
Weber, Julia
Rad, Roland
Bradley, Allan https://orcid.org/0000-0002-2349-8839
Cadiñanos, Juan
Abstract
We have recently performed a whole-body, genome-wide screen in mice using a single-copy inactivating transposon for the identification of Pten (phosphatase and tensin homolog)-cooperating tumor suppressor genes (TSGs). We identified known and putative TSGs in multiple cancer types and validated the functional and clinical relevance of several promising candidates for human prostate cancer.
Description
Keywords
AKAP13, CELF2, PARD3, PTEN, Sleeping Beauty, WAC, ZBTB20, prostate cancer, transposon, tumor suppressor gene
Journal Title
Mol Cell Oncol
Conference Name
Journal ISSN
2372-3556
2372-3556
2372-3556
Volume Title
4
Publisher
Informa UK Limited