Targeted regeneration of bone in the osteoporotic human femur.
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Peer-reviewed
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Abstract
We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.
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Keywords
Aged, Bone Density, Bone Regeneration, Diagnostic Imaging, Female, Femur, Humans, Middle Aged, Osteoporosis, Tomography, X-Ray Computed, Weight-Bearing
Journal Title
PLoS One
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Journal ISSN
1932-6203
1932-6203
1932-6203
Volume Title
6
Publisher
Public Library of Science (PLoS)
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Arthritis Research Uk (None)
Arthritis Research Uk (None)
Arthritis Research Uk (None)