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Targeted regeneration of bone in the osteoporotic human femur.

Published version
Peer-reviewed

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Type

Article

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Authors

Poole, Kenneth ES 
Treece, Graham M 
Ridgway, Gerard R 
Mayhew, Paul M 
Borggrefe, Jan 

Abstract

We have recently developed image processing techniques for measuring the cortical thicknesses of skeletal structures in vivo, with resolution surpassing that of the underlying computed tomography system. The resulting thickness maps can be analysed across cohorts by statistical parametric mapping. Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness.

Description

Keywords

Aged, Bone Density, Bone Regeneration, Diagnostic Imaging, Female, Femur, Humans, Middle Aged, Osteoporosis, Tomography, X-Ray Computed, Weight-Bearing

Journal Title

PLoS One

Conference Name

Journal ISSN

1932-6203
1932-6203

Volume Title

6

Publisher

Public Library of Science (PLoS)
Sponsorship
Arthritis Research Uk (None)
Arthritis Research Uk (None)