Collagen-Inspired Self-Assembly of Twisted Filaments.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Falk, Martin J
Duwel, Amy
Colwell, Lucy J
Brenner, Michael P
Abstract
Collagen consists of three peptides twisted together through a periodic array of hydrogen bonds. Here we use this as inspiration to find design rules for programmed specific interactions for self-assembling synthetic collagenlike triple helices, starting from disordered configurations. The assembly generically nucleates defects in the triple helix, the characteristics of which can be manipulated by spatially varying the enthalpy of helix formation. Defect formation slows assembly, evoking kinetic pathologies that have been observed to mutations in the primary collagen amino acid sequence. The controlled formation and interaction between defects gives a route for hierarchical self-assembly of bundles of twisted filaments.
Description
Keywords
Amino Acid Sequence, Collagen, Models, Chemical, Models, Molecular, Nanostructures, Peptides, Protein Conformation, alpha-Helical
Journal Title
Phys Rev Lett
Conference Name
Journal ISSN
0031-9007
1079-7114
1079-7114
Volume Title
123
Publisher
American Physical Society (APS)
Publisher DOI
Rights
All rights reserved
Sponsorship
Simons Foundation (598399)