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Repurposing of medications for pulmonary arterial hypertension

Published version
Peer-reviewed

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Authors

Spiekerkoetter, Edda 
Bogaard, Harm 
Hansmann, Georg 
Nikkho, Sylvia 

Abstract

This manuscript on drug repurposing incorporates the broad experience of members of the Pulmonary Vascular Research Institute’s Innovative Drug Development Initiative as an open debate platform for academia, the pharmaceutical industry and regulatory experts surrounding the future design of clinical trials in pulmonary hypertension. Drug repurposing, use of a drug in a disease for which it was not originally developed, in pulmonary arterial hypertension has been a remarkable success story, as highlighted by positive large phase 3 clinical trials using epoprostenol, bosentan, iloprost, and sildenafil. Despite the availability of multiple therapies for pulmonary arterial hypertension, mortality rates have modestly changed. Moreover, pulmonary arterial hypertension patients are highly symptomatic and frequently end up on parental therapy and lung transplant waiting lists. Therefore, an unmet need for new treatments exists and drug repurposing may be an important avenue to address this problem.

Description

Keywords

Review Article, pulmonary hypertension, preclinical studies, drug repurposing

Journal Title

Pulmonary Circulation

Conference Name

Journal ISSN

2045-8940

Volume Title

10

Publisher

SAGE Publications