Artificial intelligence (AI) technologies offer novel, distinctive opportunities and pose new significant challenges to organizations that set them apart from other forms of digital technologies. This article discusses the distinct effects of AI technologies in organizations, the tensions they raise and the opportunities they present for information systems (IS) research. We explore these opportunities in term of four business capabilities: automation, engagement, insight/decision making and innovation. We discuss the differentiated effects that AI brings about and the implications for future IS research.