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Impulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1

Published version
Peer-reviewed

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Authors

Jupp, Bianca 
Pitzoi, Silvia 
Petretto, Enrico 
Mar, Adam C. 
Oliver, Yolanda Pena 

Abstract

Abstract: Impulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified, no study to date has carried out an unbiased, genome-wide approach to identify genetic markers associated with impulsivity in experimental animals. Herein we report a linkage study of a six-generational pedigree of adult rats phenotyped for one dimension of impulsivity, namely premature responding on the five-choice serial reaction time task, combined with genome wide sequencing and transcriptome analysis to identify candidate genes associated with the expression of the impulsivity trait. Premature responding was found to be heritable (h2 = 13–16%), with significant linkage (LOD 5.2) identified on chromosome 1. Fine mapping of this locus identified a number of polymorphic candidate genes, however only one, beta haemoglobin, was differentially expressed in both the founder strain and F6 generation. These findings provide novel insights into the genetic substrates and putative neurobiological mechanisms of impulsivity with broader translational relevance for impulsivity-related disorders in humans.

Description

Keywords

Article, /631/378/2649/2150, /631/378/2583, /38, /38/61, /45, /45/23, /45/43, article

Journal Title

Scientific Reports

Conference Name

Journal ISSN

2045-2322

Volume Title

10

Publisher

Nature Publishing Group UK
Sponsorship
AXA Research Fund (Le Fonds AXA pour la Recherche) (RG72952)
Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness) (PSI2015-70037-R MINECO-FEDER)