Revisiting the Impact of Local Leptin Signaling in Folliculogenesis and Oocyte Maturation in Obese Mothers
Published version
Peer-reviewed
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Type
Article
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Authors
Wołodko, Karolina https://orcid.org/0000-0003-0634-7331
Castillo-Fernandez, Juan https://orcid.org/0000-0002-0034-8029
Kelsey, Gavin https://orcid.org/0000-0002-9762-5634
Galvão, António https://orcid.org/0000-0002-7990-3071
Abstract
The complex nature of folliculogenesis regulation accounts for its susceptibility to maternal physiological fitness. In obese mothers, progressive expansion of adipose tissue culminates with severe hyperestrogenism and hyperleptinemia with detrimental effects for ovarian performance. Indeed, maternal obesity is associated with the establishment of ovarian leptin resistance. This review summarizes current knowledge on potential effects of impaired leptin signaling throughout folliculogenesis and oocyte developmental competence in mice and women.
Description
Keywords
leptin, obesity, ovary, folliculogenesis, oocyte
Journal Title
International Journal of Molecular Sciences
Conference Name
Journal ISSN
1422-0067
Volume Title
22
Publisher
MDPI
Publisher DOI
Sponsorship
Polish National Science Centre (2016/23/B/NZ4/03737, 2019/34/E/NZ4/00349)