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Zebrafish Models of Autosomal Dominant Ataxias.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Quelle-Regaldie, Ana  ORCID logo  https://orcid.org/0000-0003-0498-8741
Sobrido-Cameán, Daniel  ORCID logo  https://orcid.org/0000-0001-8239-2965
Barreiro-Iglesias, Antón  ORCID logo  https://orcid.org/0000-0002-7507-080X
Sobrido, María Jesús 

Abstract

Hereditary dominant ataxias are a heterogeneous group of neurodegenerative conditions causing cerebellar dysfunction and characterized by progressive motor incoordination. Despite many efforts put into the study of these diseases, there are no effective treatments yet. Zebrafish models are widely used to characterize neuronal disorders due to its conserved vertebrate genetics that easily support genetic edition and their optic transparency that allows observing the intact CNS and its connections. In addition, its small size and external fertilization help to develop high throughput assays of candidate drugs. Here, we discuss the contributions of zebrafish models to the study of dominant ataxias defining phenotypes, genetic function, behavior and possible treatments. In addition, we review the zebrafish models created for X-linked repeat expansion diseases X-fragile/fragile-X tremor ataxia. Most of the models reviewed here presented neuronal damage and locomotor deficits. However, there is a generalized lack of zebrafish adult heterozygous models and there are no knock-in zebrafish models available for these diseases. The models created for dominant ataxias helped to elucidate gene function and mechanisms that cause neuronal damage. In the future, the application of new genetic edition techniques would help to develop more accurate zebrafish models of dominant ataxias.

Description

Keywords

X-fragile, expanded repeats, genetic edition, hereditary dominant ataxias, neurodegenerative disorders, spinocerebellar ataxias, zebrafish, Animals, Humans, Ataxia, Disease Models, Animal, Phenotype, Spinocerebellar Degenerations, Zebrafish

Journal Title

Cells

Conference Name

Journal ISSN

2073-4409
2073-4409

Volume Title

10

Publisher

MDPI AG