Measurement of Eosinophil Kinetics In Vivo.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Farahi, Neda
Gillett, Daniel
Loutsios, Chrystalla
Peters, A Michael
Summers, Charlotte https://orcid.org/0000-0002-7269-2873
Abstract
Radiolabeled leukocyte scans are used in nuclear medicine to detect sites of infection and inflammation. We have previously demonstrated the use of clinical grade immunomagnetic beads to isolate autologous eosinophils and image their distribution in healthy volunteers. Here we describe the use of radiolabeled eosinophils coupled to single-photon emission computed tomography (SPECT) to quantify eosinophil uptake in the lungs of healthy volunteers, patients with asthma, and patients with focal eosinophilic inflammation.
Description
Title
Measurement of Eosinophil Kinetics In Vivo.
Keywords
Cell trafficking, Eosinophils, Granulocytes, Imaging, Radiolabeling, SPECT, Asthma, Eosinophilia, Eosinophils, Humans, Immunomagnetic Separation, Inflammation, Kinetics, Leukocyte Count, Radioimmunodetection, Tomography, Emission-Computed, Single-Photon
Is Part Of
Methods in Molecular Biology
Book type
Publisher
Springer US
Publisher DOI
ISBN
978-1-0716-1094-7
Sponsorship
Medical Research Council (MR/J00345X/1)