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Measurement of Eosinophil Kinetics In Vivo.

Accepted version
Peer-reviewed

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Type

Book chapter

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Authors

Farahi, Neda 
Gillett, Daniel 
Loutsios, Chrystalla 
Peters, A Michael 

Abstract

Radiolabeled leukocyte scans are used in nuclear medicine to detect sites of infection and inflammation. We have previously demonstrated the use of clinical grade immunomagnetic beads to isolate autologous eosinophils and image their distribution in healthy volunteers. Here we describe the use of radiolabeled eosinophils coupled to single-photon emission computed tomography (SPECT) to quantify eosinophil uptake in the lungs of healthy volunteers, patients with asthma, and patients with focal eosinophilic inflammation.

Description

Title

Measurement of Eosinophil Kinetics In Vivo.

Keywords

Cell trafficking, Eosinophils, Granulocytes, Imaging, Radiolabeling, SPECT, Asthma, Eosinophilia, Eosinophils, Humans, Immunomagnetic Separation, Inflammation, Kinetics, Leukocyte Count, Radioimmunodetection, Tomography, Emission-Computed, Single-Photon

Is Part Of

Methods in Molecular Biology

Book type

Publisher

Springer US

ISBN

978-1-0716-1094-7
Sponsorship
Medical Research Council (MR/J00345X/1)