The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study.
Published version
Peer-reviewed
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Repository DOI
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Authors
Porter, Josie E
Benger, Danielle
Abstract
Purpose
Moderate-to-vigorous physical activity (MVPA) positively influences bone mineral content (BMC) in prepubertal children, but it is unknown whether this relationship is partially mediated by free leptin index. The aim of this study was to examine whether the relationship between MVPA and total body less head (TBLH) BMC is mediated or moderated by free leptin index in prepubertal children.Methods
We performed a cross-sectional analysis on 401 children (194 girls) from baseline examinations of the Physical Activity and Nutrition in Childhood Study. We applied the four-way decomposition mediation analysis method to assess whether free leptin index, measured from fasted blood samples, mediated the relationship between accelerometer-measured MVPA and TBLH BMC measured by dual-energy X-ray absorptiometry.Results
MVPA had a positive controlled direct effect on TBLH BMC in girls and boys (β = 0.010 to 0.011, p < 0.05). There was no mediation or interaction between MVPA, free leptin index and TBLH BMC in girls or boys (β = -0.000 to 0.001, p > 0.05).Conclusion
Our study indicates that MVPA positively influences TBLH BMC through pathways not related to free leptin index in predominantly normal-weight prepubertal children, likely primarily through mechanical loading. The relationships between MVPA, free leptin index and TBLH BMC may be influenced by other factors such as pubertal status and adiposity, so it is unknown whether these observations extend to overweight and obese children at different stages of puberty.Description
Keywords
Growth, Bone mass, Childhood, Dxa, Accelerometery, Free Leptin Index, Prepubertal Age, Humans, Leptin, Absorptiometry, Photon, Exercise, Cross-Sectional Studies, Bone Density, Child, Female, Male
Journal Title
International journal of environmental research and public health
Conference Name
Journal ISSN
1661-7827
Volume Title
18
Publisher
Publisher DOI
Sponsorship
Medical Research Council (MC_UU_12015/3)
Department of Health (IS-BRC-1215-20014)
Department of Health (IS-BRC-1215-20014)