Autophagy in major human diseases.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Klionsky, Daniel J https://orcid.org/0000-0002-7828-8118
Petroni, Giulia
Amaravadi, Ravi K
Baehrecke, Eric H
Ballabio, Andrea https://orcid.org/0000-0003-1381-4604
Abstract
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Description
Keywords
aging, cancer, inflammation, metabolic syndromes, neurodegeneration, Animals, Autophagy, Biomarkers, Disease Susceptibility, Gene Expression Regulation, Genetic Predisposition to Disease, Homeostasis, Host-Pathogen Interactions, Humans, Organ Specificity, Signal Transduction
Journal Title
EMBO J
Conference Name
Journal ISSN
0261-4189
1460-2075
1460-2075
Volume Title
40
Publisher
Springer Science and Business Media LLC
Publisher DOI
Rights
All rights reserved