Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta).
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Bertrand, Henri Georges Michel Justin https://orcid.org/0000-0002-1082-8384
Middleton, Joseph Adam
Baker, Stuart Nicolas
Glover, Isabel
Flecknell, Paul Andrew
Abstract
This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.
Description
Keywords
Alphaxalone, neurosurgery, primate, somatosensory evoked potential, Animals, Electric Stimulation, Evoked Potentials, Somatosensory, Female, Humans, Macaca mulatta, Motor Cortex, Pregnanediones
Journal Title
Lab Anim
Conference Name
Journal ISSN
0023-6772
1758-1117
1758-1117
Volume Title
55
Publisher
SAGE Publications