Modified nucleic acids: replication, evolution, and next-generation therapeutics.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Duffy, Karen
Arangundy-Franklin, Sebastian
Holliger, Philipp
Abstract
Modified nucleic acids, also called xeno nucleic acids (XNAs), offer a variety of advantages for biotechnological applications and address some of the limitations of first-generation nucleic acid therapeutics. Indeed, several therapeutics based on modified nucleic acids have recently been approved and many more are under clinical evaluation. XNAs can provide increased biostability and furthermore are now increasingly amenable to in vitro evolution, accelerating lead discovery. Here, we review the most recent discoveries in this dynamic field with a focus on progress in the enzymatic replication and functional exploration of XNAs.
Description
Keywords
DNA, DNA Replication, Evolution, Molecular, Nucleic Acids, RNA
Journal Title
BMC Biol
Conference Name
Journal ISSN
1741-7007
1741-7007
1741-7007
Volume Title
18
Publisher
Springer Science and Business Media LLC