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Modified nucleic acids: replication, evolution, and next-generation therapeutics.

Published version
Peer-reviewed

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Type

Article

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Authors

Duffy, Karen 
Arangundy-Franklin, Sebastian 
Holliger, Philipp 

Abstract

Modified nucleic acids, also called xeno nucleic acids (XNAs), offer a variety of advantages for biotechnological applications and address some of the limitations of first-generation nucleic acid therapeutics. Indeed, several therapeutics based on modified nucleic acids have recently been approved and many more are under clinical evaluation. XNAs can provide increased biostability and furthermore are now increasingly amenable to in vitro evolution, accelerating lead discovery. Here, we review the most recent discoveries in this dynamic field with a focus on progress in the enzymatic replication and functional exploration of XNAs.

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Keywords

DNA, DNA Replication, Evolution, Molecular, Nucleic Acids, RNA

Journal Title

BMC Biol

Conference Name

Journal ISSN

1741-7007
1741-7007

Volume Title

18

Publisher

Springer Science and Business Media LLC