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In Vitro Models for Studying Respiratory Host-Pathogen Interactions.

Published version
Peer-reviewed

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Type

Article

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Authors

Barron, Sarah L 
Saez, Janire 

Abstract

Respiratory diseases and lower respiratory tract infections are among the leading cause of death worldwide and, especially given the recent severe acute respiratory syndrome coronavirus-2 pandemic, are of high and prevalent socio-economic importance. In vitro models, which accurately represent the lung microenvironment, are of increasing significance given the ethical concerns around animal work and the lack of translation to human disease, as well as the lengthy time to market and the attrition rates associated with clinical trials. This review gives an overview of the biological and immunological components involved in regulating the respiratory epithelium system in health, disease, and infection. The evolution from 2D to 3D cell biology and to more advanced technological integrated models for studying respiratory host-pathogen interactions are reviewed and provide a reference point for understanding the in vitro modeling requirements. Finally, the current limitations and future perspectives for advancing this field are presented.

Description

Keywords

host-pathogens, immunology, in vitro models, infection, lungs, pathogens, respiratory system, Animals, COVID-19, Host-Pathogen Interactions, Humans, Models, Biological, SARS-CoV-2

Journal Title

Adv Biol (Weinh)

Conference Name

Journal ISSN

2701-0198
2701-0198

Volume Title

5

Publisher

Wiley
Sponsorship
Engineering and Physical Sciences Research Council (EP/L015889/1)
EPSRC (2108865)