The Nereid on the rise: Platynereis as a model system.
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The Nereid Platynereis dumerilii (Audouin and Milne Edwards (Annales des Sciences Naturelles 1:195-269, 1833) is a marine annelid that belongs to the Nereididae, a family of errant polychaete worms. The Nereid shows a pelago-benthic life cycle: as a general characteristic for the superphylum of Lophotrochozoa/Spiralia, it has spirally cleaving embryos developing into swimming trochophore larvae. The larvae then metamorphose into benthic worms living in self-spun tubes on macroalgae. Platynereis is used as a model for genetics, regeneration, reproduction biology, development, evolution, chronobiology, neurobiology, ecology, ecotoxicology, and most recently also for connectomics and single-cell genomics. Research on the Nereid started with studies on eye development and spiralian embryogenesis in the nineteenth and early twentieth centuries. Transitioning into the molecular era, Platynereis research focused on posterior growth and regeneration, neuroendocrinology, circadian and lunar cycles, fertilization, and oocyte maturation. Other work covered segmentation, photoreceptors and other sensory cells, nephridia, and population dynamics. Most recently, the unique advantages of the Nereid young worm for whole-body volume electron microscopy and single-cell sequencing became apparent, enabling the tracing of all neurons in its rope-ladder-like central nervous system, and the construction of multimodal cellular atlases. Here, we provide an overview of current topics and methodologies for P. dumerilii, with the aim of stimulating further interest into our unique model and expanding the active and vibrant Platynereis community.
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Funder: RITMARE - Flag project
Funder: Hibbitt Startup Funds
Funder: PON-MODO project
Funder: MARES Consortium
Funder: ASSEMBLE
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Ligue Contre le Cancer (RS20/75-20)
Deutsche Forschungsgemeinschaft (TO563/7-1)
National Institute of General Medical Sciences (1R35GM138008-01)
LABoratoires d'EXcellence ARCANE (ANR-11-LABX-0071)
Natural Environment Research Council (NE/T001577/1)
Division of Integrative Organismal Systems (IOS-1455185)
Biotechnology and Biological Sciences Research Council (BB/T00990X/1)
LABoratoires d’EXcellence ARCANE (ANR-11-LABX-0071)
National Science Foundation (1923429)
Academia Sinica Career Development Award (AS-CDA-110-L02)
Austrian Science Fund FWF (Y413, I2972, P28970, P32190, F78)
University of Vienna (Single-cell genomics of stem cells, Rhythms of Life)
Horizon 2020 Framework Programme (Grant Agreement 81995)
Wellcome Trust (214337/Z/18/Z)
H2020 Marie Skłodowska-Curie Actions (838225, 766053)
Agence Nationale de la Recherche (ANR-16-CE91-0007, ANR-19-CE27-0027-02)
European Research Council ((FP7/2007-2013) ERC Grant Agreement 260304, (FP7/2007-2013) ERC Grant Agreement 337011, (FP7/2007–2013) ERC Grant Agreement 337011, NeuralCellTypeEvo #788921, (FP7/2007–2013) ERC Grant Agreement 260304)
ARC (PJA 20181208248)