Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.

Microglia become hypofunctional and release metalloproteases and tau seeds when phagocytosing live neurons with P301S tau aggregates.

Published version

Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/331081

Repository DOI

https://doi.org/10.17863/CAM.78526

Files

Published version (11.81 MB)

Type

Article

Authors

Brelstaff, Jack H

https://orcid.org/0000-0003-4772-8018

Mason, Matthew

https://orcid.org/0000-0003-4284-0174

Katsinelos, Taxiarchis

https://orcid.org/0000-0001-6951-3216

McEwan, William A

https://orcid.org/0000-0002-4408-0407

Ghetti, Bernardino

Abstract

[Figure: see text].

Journal Title

Science advances

Journal ISSN

2375-2548

Volume Title

7

Publisher DOI

https://doi.org/10.1126/sciadv.abg4980

Rights

Attribution 4.0 International

Sponsorship

Wellcome Trust (206248/Z/17/Z)

Collections

Jisc Publications Router