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Understanding Alzheimer's disease as a disorder of consciousness.

Published version
Peer-reviewed

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Type

Article

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Authors

Huntley, Jonathan D 
Fleming, Stephen M 
Mograbi, Daniel C 
Bor, Daniel 
Naci, Lorina 

Abstract

People with Alzheimer's disease (AD) demonstrate a range of alterations in consciousness. Changes in awareness of cognitive deficit, self-awareness, and introspection are seen early in AD, and dysfunction of awareness and arousal progresses with increasing disease severity. However, heterogeneity of deficits between individuals and a lack of empirical studies in people with severe dementia highlight the importance of identifying and applying biomarkers of awareness in AD. Impairments of awareness in AD are associated with neuropathology in regions that overlap with proposed neural correlates of consciousness. Recent developments in consciousness science provide theoretical frameworks and experimental approaches to help further understand the conscious experience of people with AD. Recognition of AD as a disorder of consciousness is overdue, and important to both understand the lived experience of people with AD and to improve care.

Description

Keywords

Alzheimer's disease, awareness, consciousness

Journal Title

Alzheimers Dement (N Y)

Conference Name

Journal ISSN

2352-8737
2352-8737

Volume Title

7

Publisher

Wiley
Sponsorship
Wellcome Clinical Research Career Development Fellowship (214547/Z/18/Z)
Wellcome/Royal Society Sir Henry Dale Fellowship (206648/Z/17/Z)
Wellcome Trust (206648/Z/17/Z, 210920/Z/18/Z)