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Neuropsychological performance in young adults with cannabis use disorder.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Selamoglu, Ayla 
Langley, Christelle  ORCID logo  https://orcid.org/0000-0001-5061-2820
Crean, Rebecca 
Savulich, George 

Abstract

BACKGROUND AND AIMS: Cannabis is a commonly used recreational drug in young adults. The worldwide prevalence in 18- to 25-year-olds is approximately 35%. Significant differences in cognitive performance have been reported previously for groups of cannabis users. However, the groups are often heterogeneous in terms of cannabis use. Here, we study daily cannabis users with a confirmed diagnosis of cannabis use disorder (CUD) to examine cognitive performance on measures of memory, executive function and risky decision-making. METHODS: Forty young adult daily cannabis users with diagnosed CUD and 20 healthy controls matched for sex and premorbid intelligence quotient (IQ) were included. The neuropsychological battery implemented was designed to measure multiple modes of memory (visual, episodic and working memory), risky decision-making and other domains of executive function using subtests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). RESULTS: Our results showed that young adult daily cannabis users with CUD perform significantly poorer on tasks of visual and episodic memory compared with healthy controls. In addition, executive functioning was associated with the age of onset. CONCLUSIONS: Further research is required to determine whether worse performance in cognition results in cannabis use or is a consequence of cannabis use. Chronic heavy cannabis use during a critical period of brain development may have a particularly negative impact on cognition. Research into the persistence of cognitive differences and how they relate to functional outcomes such as academic/career performance is required.

Description

Funder: NIHR MedTech


Funder: in vitro diagnostic Co-operative


Funder: nihr cambridge biomedical research centre


Funder: Wallitt Foundation and Eton College


Funder: Wellcome Trust Collaborative Award

Keywords

CANTAB, Cognition, cannabis use disorder, Adult, California, Cognitive Dysfunction, Female, Humans, Male, Marijuana Abuse, Neuropsychological Tests, Psychomotor Performance, Young Adult

Journal Title

J Psychopharmacol

Conference Name

Journal ISSN

0269-8811
1461-7285

Volume Title

Publisher

SAGE Publications
Sponsorship
national institute on drug abuse (DA026758)
NIDA NIH HHS (R01 DA026758)
Wellcome Trust (200181/Z/15/Z)