ETV6-RUNX1 and RUNX1 directly regulate RAG1 expression: one more step in the understanding of childhood B-cell acute lymphoblastic leukemia leukemogenesis.
Published version
Peer-reviewed
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Type
Article
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Authors
Jakobczyk, Hélène
Soubise, Benoit
Avner, Stéphane
Abstract
ETV6-RUNX1 and RUNX1 directly promote RAG1 expression. ETV6-RUNX1 and RUNX1 preferentially bind to the −1200 bp enhancer of RAG1 and the −80 bp promoter of RAG1 gene respectively, and compete for these bindings. ETV6-RUNX1 and RUNX1 induce an excessive RAG recombinase activity. ETV6-RUNX1 participates directly in two events of the multi-hit ALL leukemogenesis: as an initiating event and as an activator of RAG1 expression.
Description
Funder: Société Française de Biochimie et Biologie Moléculaire ; French Research Ministry
Funder: Cancéropole Grand Ouest ; Région Bretagne ; Société Française d’Hématologie
Funder: Ligue Régionale contre le cancer ;
Keywords
Cell Transformation, Neoplastic, Core Binding Factor Alpha 2 Subunit, Gene Expression Regulation, Leukemic, Homeodomain Proteins, Humans, Oncogene Proteins, Fusion, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Tumor Cells, Cultured
Journal Title
Leukemia
Conference Name
Journal ISSN
0887-6924
1476-5551
1476-5551
Volume Title
36
Publisher
Springer Science and Business Media LLC
