In 1920, Hermann Staudinger put forward the concept that rubber is composed of isoprene units, which has been considered as the beginning of “macromolecular science” or “polymer science.” The past 100 years’ development of polymer science has witnessed the greatness and foresight of this ground breaking theory. On the occasion of the 100th anniversary of the birth of polymer science, this paper is dedicated to recalling a piece of research history on rubber